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    <ns1:strainDevelopment xml:lang="en">Developed by Yoshifumi Yamaguchi and Shinji Takada, Okazaki Institute for Integrative Bioscience in 2005.  CJ7 (129S1/Sv-Oca2&lt;+&gt; Tyr&lt;+&gt; Kitl&lt;+&gt;) ES cells derived. Floxed exon 2 was removed by crossing with CAG-cre mice.  The mutant mice were backcrossed to C57BL/6J over 5 times.</ns1:strainDevelopment>
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    <ns4:application>Cre/loxP system</ns4:application>
    <ns1:colonyMaintenance xml:lang="ja">Heterozygote x Wild-type [C57BL/6JJcl] 繁殖成績が低い ホモで不妊／死亡</ns1:colonyMaintenance>
    <ns6:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/mgi_rdf/MGI:3707688"/>
    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Dev. Dyn., 233, 484-495 (2005). Development,133, 4737-4348 (2006).&lt;br&gt;寄託者（開発者）の承諾を得る。利用者が本件リソースを使用して得られた研究成果に基づき特許等の申請、及び事業活動を行う場合は、寄託者と別途協議を行う。</ns4:termsAndConditions>
    <ns4:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Dyn., 233, 484-495 (2005). Development,133, 4737-4348 (2006).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.  The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.</ns4:termsAndConditions>
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    <dc:description xml:lang="ja">Tcfcp2l1遺伝子のノックアウトマウス。Tcfcp2l1遺伝子の第2エクソンをloxP配列で挟み、CAG-Creマウスとの交配により欠失させたもの。ホモマウスは生後致死。</dc:description>
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    <ns1:strainDevelopment xml:lang="ja">岡崎統合バイオサイエンスセンター 山口良文先生、高田慎治先生 (2005)。CJ7 (129S1/Sv-Oca2&lt;+&gt; Tyr&lt;+&gt; Kitl&lt;+&gt;) ES細胞由来。C57BL/6Jにコンジェニックされた (N5以上)。</ns1:strainDevelopment>
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    <ns6:brs_depositor xml:lang="en">Shinji TAKADA</ns6:brs_depositor>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr03118'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns1:colonyMaintenance xml:lang="en">Heterozygote x Wild-type [C57BL/6JJcl]</ns1:colonyMaintenance>
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    <ns1:donorDNA>Phage P1 loxP, mouse Tcfcp2l1 genomic DNA</ns1:donorDNA>
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    <dcterms:references rdf:resource="http://identifiers.org/pubmed/17079272"/>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
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    <skos:altLabel xml:lang="ja">Tcfcp211nu11</skos:altLabel>
    <skos:altLabel xml:lang="en">Tcfcp211nu11</skos:altLabel>
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    <dc:description xml:lang="en">Tcfcp2l1 gene knockout mice. Exon 2 of the Tcfcp2l1 gene was removed via cre mediated recombination. Homozygous mutant mice are postnatal lethal.</dc:description>
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    <ns1:colonyMaintenance xml:lang="ja">Heterozygote x Wild-type [C57BL/6JJcl]繁殖成績が低いホモで不妊／死亡</ns1:colonyMaintenance>
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    <ns6:brs_depositor xml:lang="ja">高田　慎治</ns6:brs_depositor>
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    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC03118"/>
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    <ns6:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC03118"/>
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